New research reveals that people who stop using new slimming jabs like Wegovy and Mounjaro tend to recover lost weight much more quickly than those who end conventional diet and exercise regimens.
Research printed in a prominent medical journal shows that while overweight people frequently drop substantial amounts of their body weight while undergoing treatment, the weight is regained at an average rate of 0.8 kg per month after stopping.
"Users purchasing such treatments must be aware of the danger of rapid weight regain when the medication ends," warns lead investigator Dr. Susan Jebb.
Such speed of regain suggests a reversion to starting weight in about 18 months.
Analyzing Approaches
The study, which looked at dozens of trials involving thousands of patients, contrasted the results of the injectable medications with older methods.
Researchers emphasize that people who shed pounds through lifestyle changes alone typically have a more gradual creep back—perhaps 0.1 kg a month—after stopping.
Explaining the Quick Rebound
Doctors propose the mode of action of the drugs explains the heightened rebound.
GLP-1 drugs mimic a body's own chemical called glucagon-like peptide-1, which controls appetite.
"Long-term administration of the hormone concentrations several times higher than the body's typical production may cause the body to generate a reduced amount of its own natural hormone, and may also reduce responsiveness to its actions," said Dr. Adam Collins, a nutrition expert.
"Discontinuation of this medication means hunger is uncontrolled, making binge eating much more probable."
A Chronic Issue?
Health authorities suggest the injections for people with weight-linked health risks, alongside recommended lifestyle changes.
Many experts say that, given the significant potential of weight regain, the therapy is often long-term.
This opinion is supported by drug manufacturers, who state that the results "underscore the persistent nature of excess weight," comparing it to managing diseases like high blood pressure.
User Testimonies
Users who have come off the jabs explain a powerful resurgence of hunger.
"It was like something activating and you're instantly extremely hungry," described one woman.
The struggle is exacerbated if individuals have not developed permanent lifestyle or habit changes during treatment.
Widespread Interest
Figures suggest that a significant number of people in the UK have used weight-loss jabs in the past year, with demand being substantial.
- Use is more common among females than men.
- The middle-aged demographic shows the highest level of interest.
- A large proportion access the drugs through private healthcare rather than the NHS.
Finally, researchers emphasize that while GLP-1 drugs are effective tools for weight loss, they are not a standalone solution and lasting health benefits likely depends on ongoing lifestyle support.
